Ce topic appartient à l'appel Circular economy and bioeconomy sectors
Identifiant du topic: HORIZON-CL6-2022-CIRCBIO-02-02-two-stage

Exploring extreme environments: novel adaptation strategies at molecular level for bio-based innovation

Type d'action : HORIZON Research and Innovation Actions
Nombre d'étapes : Two stage
Date d'ouverture : 28 octobre 2021
Date de clôture 1 : 15 février 2022 17:00
Date de clôture 2 : 01 septembre 2022 17:00
Budget : €10 000 000
Call : Circular economy and bioeconomy sectors
Call Identifier : HORIZON-CL6-2022-CIRCBIO-02-two-stage
Description :


Projects will contribute to the expected impacts identified for Destination ‘Circular economy and bioeconomy sectors’, and to the European policies it supports, in particular the European Green Deal, the circular economy action plan and the Bioeconomy and biodiversity strategies. Their results will help to improve the European industrial[1] sustainability, competitiveness and resource independence by lowering the environmental footprint (including on biodiversity), enabling climate-neutrality and higher resource efficiency (in particular upcycling and cascading use of biomass) along and across value chains, developing innovative bio-based products. They will engage all stakeholders and improve their knowledge and understanding of science, in particular biotechnology-based value chains

Projects results should contribute to all of the following expected outcomes:

Deeper understanding of the molecular, biochemical and cellular mechanisms of ecological adaptation of terrestrial and aquatic organisms in response to life under extreme or changing environments, while strengthening the remediation options at macro level for the studied populations, including by their interactions, thus contributing to expanding the range of potential climate change mitigation strategies.

  • Stronger innovation capacity by applying the discovered principles (including via biotechnology routes) to the development of more resilient innovative feedstocks needed for sustainable bio-based products[2]
  • A significantly improved environmental footprint of novel feedstocks based on discovered principles[3], and a wider range of sustainable biomass resources available to European industry, that are important for industrial competitiveness and SMEs participation, thus helping to create skilled jobs and boost the economy.
  • Increased public understanding in Europe of biotechnology, the conservation of biodiversity, and EU biodiversity strategy goals. Respect of the principles of access and benefit sharing (UN Biodiversity Convention), via clear, inclusive and transparent communication strategies.


The topic covers R&D needed to advance and potentially exploit knowledge on the ways terrestrial and aquatic organisms and their populations adapt, on molecular, physiological, and ecological levels, to the effects of climate change, such as by tolerance to extreme temperatures, drought/water stress, salinity or increased biotic pressures (new pests), as observed at macro-scale (e.g. shifting ecological niches). The scope covers understanding the complex interactions between the affected populations (e.g. molecular signalling), and broader outcomes on an ecological level. International cooperation is strongly encouraged to maximise the impact.

Where relevant, proposals should seek synergies and capitalise on the results of past and ongoing research projects. Proposals should:

  1. Identify and justify the choice of the selected organism or system under investigation, specifying the level and characteristics of the environmental stimuli covered (i.e. extreme or changing environment linked to climatic conditions).
  2. Consider the broader level of climate adaptation in the systems identified, in order to shed light on the possibility and magnitude of applying the discovered principles as part of a mitigation strategy.
  3. Engage with industrial actors including SMEs to identify and implement the best combination of appropriate technical solutions and in particular biotechnology for specific industrial value chains, for sustainable biomass generation, taking into account the barriers and drivers derived from governance and market aspects, while seeking engagement and understanding of all actors.
  4. Develop and communicate the key methods to monitor and measure the qualitative and quantitative impacts of these solutions and practices for different biomass sourcing, optimization, processing and production systems, the potential of replacing available traditional alternatives, if relevant, and trade-offs, including for biodiversity, and potential benefits in terms of the socioeconomic resilience of businesses, job creation and industrial competitiveness.
  5. Develop and test mechanisms with all actors, notably the research community and bio-based industry. Exchange knowledge on and demonstrate solutions for improved bio-based products and processes and for addressing other environmental impacts such as on biodiversity to agricultural operators, farmers, fishers, foresters, SMEs and the broader public, and help them implement them.

For this topic, it is not mandatory to integrate the gender dimension (sex and gender analysis) into research and innovation.

Specific Topic Conditions:


Activities are expected to achieve TRL 4-5 by the end of the project – see General Annex B.


Cross-cutting Priorities:

International Cooperation
Digital Agenda
Artificial Intelligence

[1]In connection with European partnerships under Cluster 6, in particular Circular Bio-based Europe (CBE).

[2]i.e. molecular traits linked with sustainable intensification of production, quality of the concerned feedstocks, or enhanced defence ability

[3]e.g. through lowered requirements for pesticides or irrigation.